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That’s one of the fundamental disagreements between Catholics and Protestants.
A Catholic would argue that veneration of saints isn’t worship, it’s showing respect for someone who exemplified Christian ideals, or died as a martyr. Canonization is basically the religious version of the Medal of Honor.
A Protestant would argue that the distinction between veneration and worship is arbitrary, and veneration of a saint essentially amounts to idolatry anyway.
Some applications use those unused bits to add tags to pointers but it’s important to mask those out before attempting to dereference the address. I’m not sure about ARM but x86-64 requires bits 49-63 to be copies of bit 48 (kinda like sign-extension), ironically to ensure that no one is using those bits to store extra data.