F-Zero 99 has proven the viability of OG FZero gameplay on for modern fans.
My thoughts:
Fans are going to say "This means you should make a new #FZero successor to FZeroGX".
I'm going to disagree.
What this actually means is you should make F-Zero Maker as a successor to Mario Maker.
The OG tracks are 2D and simple, they could very easily be hand-made by players in an editor.
Excellent, Sega made the Yakuza and Shenmue games too, and the F-Zero setting is canonically about bounty hunters and crooks racing as a hobby. It would make perfect sense to have Sega return to the F-Zero franchise to make an open-world game in a crime-ridden interplanetary dystopia about racing, car-chases, and punching things.