Mark Lawrence has several trilogies that fit into this genre. They’re fantasy books but the setting/universe is based on science fiction.

Series that I’ve read and recommend:

Broken Empire

Holy Sister

Red Queens War

I found them all an enjoyable mix of dark/grim fantasy with a good mix of humor. These series all tend to follow an anti-hero or in Broken Empire’s case you could argue it’s a villain protagonist given just how unsavory a character Jorg is. Even still I found myself liking and rooting for that bastard.

The Broken Earth series is really original and well written.

Wait, Gormenghast has Science fiction? When does that show up? I only read the first book so far and don’t remember a lot.

Mark Lawrence’s “Book of the Ancestor” and “Book of the Ice” series.

Someone else suggested N.K. Jemisin’s Broken Earth series, which is also an unusual take on the post-apocalyptic and survivalism stuff that a lot of people are into these days.

• The City We Became and The Broken Earth series by N.K. Jemisin.
• Light From Uncommon Stars by Ryka Aoki
• Remote Control by Nnedi Okorafor

Stephen King’s Dark Tower series. Mix of cyberpunk post-apocalyptic parallel universes with science so deep it’s magic.

(Trying not to give away too many spoilers!)

As a bonus, there’s an extended reading list which ties the Dark Tower into books and short stories from King’s universe.

• The Captain by Will Wight
• The Shadows of Dust by Alec Hutson
• Portal to Nova Roma by J.R. Mathews
• Starship’s Mage by Glynn Stewart