Depends on how much you rely on it. If your contacts can’t phone or otherwise contact you for your new address, they’re gone.
If the services you use don’t mail you OTP codes on every log in, you can still log in using your old email and update it.
You can also contact customer support of some services and have them change it, using other ways to autheticate, e.g. physical letters with generated OTP codes.
The big religions have omnipotent or near omnipotent gods that can appear in any form or gender. One of their powers is usually shapeshifting. So they are whaterver sex they want, sometimes even none, like for example the christian god appeared as pillars of cloud or fire.