Examples include: Scary Game Squad, Gamegrumps, Team Double Dragon, and the like.
I just find let's plays a lot more entertaining when multiple people are playing and chatting than when it's just one person rambling. But these are weirdly hard to search for!
Well, not dedicated to that, but mr samuel streamer (mostly crusader kings and rimworld) has an alt channel where he shoots the shit with his fiance, and sometimes they play games together. They're playing vampire: the masquerade: bloodlines rn.